Since Percocet is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember.
Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose. What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1 An overdose of Percocet can be fatal. The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness.
Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes. Overdose symptoms may also include extreme drowsiness, pinpoint pupils, cold and clammy skin, muscle weakness, fainting, weak pulse, slow heart rate, coma, blue lips, shallow breathing, or no breathing What should I avoid while taking Percocet?
Percocet may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen sometimes abbreviated as APAP is contained in many combination medicines.
Taking certain products together can cause you to get too much acetaminophen. Increase in glucuronidation resulting in increased plasma clearance and a decreased half-life of acetaminophen. Reduces acetaminophen absorption when administered as soon as possible after overdose. Propanolol appears to inhibit the enzyme systems responsible for the glucuronidation and oxidation of acetaminophen.
Therefore, the pharmacologic effects of acetaminophen may be increased. The effects of the loop diuretic may be decreased because acetaminophen may decrease renal prostaglandin excretion and decrease plasma renin activity. Serum lamotrigine concentrations may be reduced, producing a decrease in therapeutic effects.
Probenecid may increase the therapeutic effectiveness of acetaminophen slightly. The pharmacologic effects of zidovudine may be decreased because of enhanced non-hepatic or renal clearance of zidovudine.
A more specific alternate chemical method must be used in order to obtain a confirmed analytical result. Moreover, clinical considerations and professional judgment should be applied to any drug-of-abuse test result, particularly when preliminary positive results are used. This effect appears to be drug, concentration and system dependent. Such drugs are sought by drug abusers and people with addiction disorders and are subject to criminal diversion.
Oxycodone can be abused in a manner similar to other opioid agonists, legal or illicit. This should be considered when prescribing or dispensing PERCOCET tablets in situations where the physician or pharmacist is concerned about an increased risk of misuse, abuse, or diversion. Concerns about misuse, addiction, and diversion should not prevent the proper management of pain. Healthcare professionals should contact their State Professional Licensing Board or State Controlled Substances Authority for information on how to prevent and detect abuse or diversion of this product.
Elderly and debilitated patients are at particular risk for respiratory depression as are non-tolerant patients given large initial doses of oxycodone or when oxycodone is given in conjunction with other agents that depress respiration.
Oxycodone should be used with extreme caution in patients with acute asthma, chronic obstructive pulmonary disorder COPD , cor pulmonale , or preexisting respiratory impairment. In such patients, even usual therapeutic doses of oxycodone may decrease respiratory drive to the point of apnea. In these patients alternative non-opioid analgesics should be considered, and opioids should be employed only under careful medical supervision at the lowest effective dose.
Head Injury and Increased Intracranial Pressure The respiratory depressant effects of opioids include carbon dioxide retention and secondary elevation of cerebrospinal fluid pressure, and may be markedly exaggerated in the presence of head injury , other intracranial lesions or a pre-existing increase in intracranial pressure. Oxycodone produces effects on pupillary response and consciousness which may obscure neurologic signs of worsening in patients with head injuries.
Hypotensive Effect Oxycodone may cause severe hypotension particularly in individuals whose ability to maintain blood pressure has been compromised by a depleted blood volume, or after concurrent administration with drugs which compromise vasomotor tone such as phenothiazines.
Oxycodone, like all opioid analgesics of the morphine-type, should be administered with caution to patients in circulatory shock, since vasodilation produced by the drug may further reduce cardiac output and blood pressure. Oxycodone may produce orthostatic hypotension in ambulatory patients. Hepatotoxicity Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed milligrams per day, and often involve more than one acetaminophen containing product.
The excessive intake of acetaminophen may be intentional to cause self-harm or unintentional as patients attempt to obtain more pain relief or unknowingly take other acetaminophen-containing products.
The risk of acute liver failure is higher in individuals with underlying liver disease and in individuals who ingest alcohol while taking acetaminophen. Oxycodone is an opioid pain medication.
An opioid is sometimes called a narcotic. Acetaminophen is a less potent pain reliever that increases the effects of oxycodone. Percocet is used to relieve moderate to severe pain.
Percocet may also be used for purposes not listed in this medication guide. Slideshow Important information You should not use Percocet if you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications.
This medicine can slow or stop your breathing, and may be habit-forming. Use only your prescribed dose, and swallow the pill whole to avoid a potentially fatal dose.
Never share Percocet with another person. Do not use Percocet if you have used a MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Do not take more Percocet than is recommended. An overdose of acetaminophen can damage your liver or cause death.
Call your doctor at once if you have nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, or jaundice yellowing of your skin or eyes. Oxycodone may cause life-threatening withdrawal symptoms in a newborn if the mother has taken this medicine during pregnancy.
Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing. Before taking this medicine You should not use Percocet if you are allergic to acetaminophen Tylenol or oxycodone, or if: Some medicines can interact with oxycodone and cause a serious condition called serotonin syndrome.
Physical dependence on a prescribed medication does not signify addiction. Physical dependence involves the occurrence of a withdrawal syndrome when there is sudden reduction or cessation in drug use or if an opiate antagonist is administered. Physical dependence can be detected after a few days of opioid therapy. However, clinically significant physical dependence is only seen after several weeks of relatively high dosage therapy.
In this case, abrupt discontinuation of the opioid may result in a withdrawal syndrome. This medication may impair your thinking or reactions.
Avoid driving or operating machinery until you know how acetaminophen and oxycodone will affect you. Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication.
Acetaminophen sometimes abbreviated as APAP is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP. It may increase your risk of liver damage while taking acetaminophen. What other drugs will affect acetaminophen and oxycodone? Do not take acetaminophen and oxycodone with any other narcotic pain medications , sedatives, tranquilizers, sleeping pills, muscle relaxers, or other medicines that can make you sleepy or slow your breathing.
Dangerous side effects may result.
Oxycodone alone was negative in a bacterial reverse mutation assay Amesan in vitro chromosome aberration assay with human lymphocytes without metabolic activation and an in vivo mouse micronucleus assay. Geriatric Use Special precaution should be given when determining the dosing amount and frequency of PERCOCET tablets for geriatric patients, since clearance of oxycodone may be slightly reduced in this patient population when compared to younger patients. The opioid antagonist naloxone hydrochloride is a specific antidote against respiratory depression which percocet result from overdosage or unusual sensitivity to opioids, including oxycodone. Assisted or controlled ventilation should also be considered. Do not drink alcohol. The withdrawal syndrome of oxycodone is similar to that of morphine. Take Percocet exactly as prescribed. To obtain the best possible outcome, NAC should be administered as 650 as possible where impending or evolving liver injury is suspected. You may not be able to take medication that contains acetaminophen. 650 effect appears to be drug, concentration and system dependent. Interactions with Alcohol percocet Drugs of Abuse Oxycodone may be expected to have additive effects when used in conjunction 650 alcohol, other opioids, or illicit drugs that cause central nervous system percocet. In addition, abuse of opioids can occur in the absence of true addiction and is characterized by misuse for non-medical purposes, 650 mg of percocet, often in combination with other psychoactive substances. Propanolol appears to inhibit the enzyme systems responsible for the glucuronidation and oxidation of acetaminophen. Acetaminophen is also excreted in breast milk in low concentrations. Clinical and laboratory evidence of hepatic toxicity may not be apparent until 48 to 72 hours post-ingestion. Oxycodone is contraindicated in the setting of suspected or known paralytic ileus.
Opioid use during pregnancy may result in a physically drug-dependent fetus. The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, 650 mg of percocet, stomach pain, percocet, and confusion or weakness. Opioid addiction is relatively rare in patients with chronic pain percocet may be more common in individuals who 650 a past history of alcohol or substance abuse or dependence. Pediatric Use Safety and effectiveness in pediatric patients have not otc prevacid review established. Copyright Cerner Multum, Inc. This syndrome is characterized by yawninganxiety, increased heart rate and blood pressure, restlessness, nervousness, muscle aches, tremor, irritability, chills alternating with hot flashessalivation, anorexiasevere sneezing, lacrimationrhinorrheadilated pupils, diaphoresis, piloerectionnausea, vomiting, abdominal cramps, diarrhea and insomnia, and pronounced weakness and depression. Therefore, the pharmacologic effects of acetaminophen may be increased. Less serious Percocet 650 effects include: Acetaminophen is also excreted in breast milk in low concentrations. This syndrome is characterized by yawninganxiety, increased heart rate and blood pressure, restlessness, nervousness, muscle aches, tremor, irritability, chills alternating with hot flashessalivation, anorexiasevere sneezing, lacrimationrhinorrheadilated pupils, diaphoresis, piloerection650 mg of percocet, nausea, vomiting, abdominal cramps, diarrhea and insomnia, and pronounced weakness and depression. Nursing mothers should consult with their physicians about whether to discontinue nursing or discontinue PERCOCET tablets because of the potential for serious adverse reactions to nursing infants. FDA pregnancy category C. Keep the medication in a place where others cannot get to it. Tell your doctor if you need to use any of these other medicines while you are taking Percocet.
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