Very bad belly pain. Not able to eat. Feeling very tired or weak. Dark urine or yellow skin or eyes. Back pain, belly pain, or blood in the urine. May be signs of a kidney stone. Side effect or health problem is not better or you are feeling worse. Can I take Orlistat with other medicines: Sometimes drugs are not safe when you take them with certain other drugs and food. Store in a cool, dry place away from the reach of children.
Pregnancy Category Category X: Studies in animals or humans have demonstrated fetal abnormalities andor there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
Missed Dose If you miss a dose resume taking Xenical at the next meal. Do not try to make up the loss with a double dose. The extra drug will not help.
Possible Side Effects Stop taking Xenical and seek emergency medical attention if you experience a rare allergic reaction including shortness of breath; closing of your throat; swelling of your lips, tongue, or face; or hives. Other, less serious side effects are more likely to occur.
Continue to take Xenical and talk to your doctor if you experience oily spotting, gas with discharge, an urgent need to go to the bathroom, oily or fatty stools, an oily discharge, an increased number of bowel movements, an inability to control bowel movements, or orange or brown colored oil in your stool.
The bowel changes listed above are a natural effect of blocking fat and indicate that Xenical is working. They generally occur early in treatment, particularly after meals containing higher amounts of fat than are recommended. Side effects other than those listed here may also occur.
Talk to your doctor about any side effect that seems unusual or that is especially bothersome. Storage Store this medication at room temperature and out of the reach of children. Keep container tightly closed. Throw away any unused medicine after the expiration date. When lipase activity is blocked, triglycerides from the diet are not hydrolyzed into absorbable free fatty acids , and instead are excreted unchanged. Only trace amounts of orlistat are absorbed systemically; the primary effect is local lipase inhibition within the GI tract after an oral dose.
The primary route of elimination is through the feces. Orlistat was also recently found to inhibit the thioesterase domain of fatty acid synthase FAS , an enzyme involved in the proliferation of cancer cells but not normal cells. However, potential side effects of Orlistat, such as inhibition of other cellular off-targets or poor bioavailability, might hamper its application as an effective antitumor agent.
One profiling study undertook a chemical proteomics approach to look for new cellular targets of orlistat, including its off-targets. In Australia, the European Union , [30] and the United States, certain formulations of orlistat have been approved for sale without a prescription.
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