If cholelithiasis is suspected, gallbladder studies are indicated. Gemfibrozil therapy should be discontinued if gallstones are found. Cases of cholelithiasis have been reported with Gemfibrozil therapy. If a significant serum lipid response is not obtained, Gemfibrozil should be discontinued.

Concomitant Anticoagulants — Caution should be exercised when warfarin is given in conjunction with Gemfibrozil. The dosage of warfarin should be reduced to maintain the prothrombin time at the desired level to prevent bleeding complications. Frequent prothrombin determinations are advisable until it has been definitely determined that the prothrombin level has stabilized. Concomitant therapy with Gemfibrozil and an HMG-CoA reductase inhibitor is associated with an increased risk of skeletal muscle toxicity manifested as rhabdomyolysis, markedly elevated creatine kinase CPK levels, and myoglobinuria, leading in a high proportion of cases to acute renal failure and death.

The use of fibrates alone, including Gemfibrozil, may occasionally be associated with myositis. Patients receiving Gemfibrozil and complaining of muscle pain, tenderness, or weakness should have prompt medical evaluation for myositis, including serum creatine—kinase level determination.

If myositis is suspected or diagnosed, Gemfibrozil therapy should be withdrawn. Initial Therapy — Laboratory studies should be done to ascertain that the lipid levels are consistently abnormal. Before instituting Gemfibrozil therapy, every attempt should be made to control serum lipids with appropriate diet, exercise, weight loss in obese patients, and control of any medical problems such as diabetes mellitus and hypothyroidism that are contributing to the lipid abnormalities.

Continued Therapy — Periodic determination of serum lipids should be obtained, and the drug withdrawn if lipid response is inadequate after three months of therapy. The risk of myopathy and rhabdomyolysis is increased with combined Gemfibrozil and HMG-CoA reductase inhibitor therapy.

Myopathy or rhabdomyolysis with or without acute renal failure have been reported as early as three weeks after initiation of combined therapy or after several months see WARNINGS. There is no assurance that periodic monitoring of creatine kinase will prevent the occurrence of severe myopathy and kidney damage. In healthy volunteers, co-administration with Gemfibrozil mg twice daily for 3 days resulted in an 8.

In healthy volunteers given a single mg dose of enzalutamide after Gemfibrozil mg twice daily, the AUC of enzalutamide plus active metabolite N-desmethyl enzalutamide was increased by 2. Increased enzalutamide exposure may increase the risk of seizures.

F Bile Acid-Binding Resins: Administration of the drugs two hours or more apart is recommended because Gemfibrozil exposure was not significantly affected when it was administered two hours apart from colestipol. Myopathy, including rhabdomyolysis, has been reported with chronic administration of colchicine at therapeutic doses.

Concomitant use of Gemfibrozil may potentiate the development of myopathy. Patients with renal dysfunction and elderly patients are at increased risk.

Caution should be exercised when prescribing Gemfibrozil with colchicine, especially in elderly patients or patients with renal dysfunction. Carcinogenesis, Mutagenesis, Impairment of Fertility — Long-term studies have been conducted in rats at 0. The incidence of benign liver nodules and liver carcinomas was significantly increased in high dose male rats.

Male rats had a dose-related and statistically significant increase of benign Leydig cell tumors. The higher dose female rats had a significant increase in the combined incidence of benign and malignant liver neoplasms. Long-term studies have been conducted in mice at 0. There were no statistically significant differences from controls in the incidence of liver tumors, but the doses tested were lower than those shown to be carcinogenic with other fibrates.

Electron microscopy studies have demonstrated a florid hepatic peroxisome proliferation following Gemfibrozil administration to the male rat. An adequate study to test for peroxisome proliferation has not been done in humans but changes in peroxisome morphology have been observed.

Peroxisome proliferation has been shown to occur in humans with either of two other drugs of the fibrate class when liver biopsies were compared before and after treatment in the same individual. Administration of approximately 2 times the human dose based on surface area to male rats for 10 weeks resulted in a dose-related decrease of fertility. Subsequent studies demonstrated that this effect was reversed after a drug-free period of about eight weeks, and it was not transmitted to the offspring.

Pregnancy Category C — Gemfibrozil has been shown to produce adverse effects in rats and rabbits at doses between 0. There are no adequate and well-controlled studies in pregnant women. Gemfibrozil should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Administration of Gemfibrozil to female rats at 2 times the human dose based on surface area before and throughout gestation caused a dose-related decrease in conception rate, an increase in still borns, and a slight reduction in pup weight during lactation.

There were also dose-related increased skeletal variations. Anophthalmia occurred, but rarely. Administration of 1 and 3 times the human dose based on surface area of Gemfibrozil to female rabbits during organogenesis caused a dose-related decrease in litter size and, at the high dose, an increased incidence of parietal bone variations. Nursing Mothers — It is not known whether this drug is excreted in human milk.

Because many drugs are excreted in human milk and because of the potential for tumorigenicity shown for Gemfibrozil in animal studies, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Hematologic Changes — Mild hemoglobin, hematocrit, and white blood cell decreases have been observed in occasional patients following initiation of Gemfibrozil therapy. However, these levels stabilize during long-term administration.

Rarely, severe anemia, leukopenia, thrombocytopenia, and bone marrow hypoplasia have been reported. Therefore, periodic blood counts are recommended during the first 12 months of Gemfibrozil administration. These are usually reversible when Gemfibrozil is discontinued. Therefore, periodic liver function studies are recommended and Gemfibrozil therapy should be terminated if abnormalities persist.

In such patients, the use of alternative therapy should be considered against the risks and benefits of a lower dose of Gemfibrozil. Pediatric Use — Safety and efficacy in pediatric patients have not been established. Adverse Reactions In the double-blind controlled phase of the primary prevention component of the Helsinki Heart Study, patients received Gemfibrozil for up to five years.

In that study, the following adverse reactions were statistically more frequent in subjects in the Gemfibrozil group: Is that harmful to be taking? Gemfibrozil Lopid is a prescription medication used to reduce levels of triglycerides a fat-like substance and cholesterol in the body.

Gemfibrozil is part of a class of drugs known as fibric acid derivatives. It is believed to work by slowing down the production of triglycerides in the liver. The medication also causes an increase in HDL good cholesterol. The most common side effects are stomach upset, indigestion, diarrhea, fatigue, nausea and vomiting. The use of gemfibrozil has been associated with a rare but serious side effect known as rhabdomyolysis serious breakdown of muscle.

Contact your health care provider, immediately, if you experience any unexplained muscle pain, tenderness, or weakness, especially if accompanied by a fever or unusual tiredness. For more information about gemfibrozil: What is a substitute for gemfibrozil? The VA no longer has it and I can't get an appointment to ask a doctor. Cholesterol is a sticky, waxy substance that is found naturally in the body and is ingested in the foods that we eat.

Cholesterol is used to digest the foods that we eat and to produce hormones and vitamin D. However, too much cholesterol can lead to buildup in the arteries which can, over time, lead to plaques or blockage of the arteries. LDL is often times referred to as "bad" cholesterol since it can cause increased levels of cholesterol in the arteries. HDL is often referred to as "good" cholesterol because it carries cholesterol to the liver which then excretes it from the body.

There are many different medications that are used in the treatment of high cholesterol. Statins are commonly used since they are very effective at lowering LDL. However, there are other classes of medications that are frequently used. Some of these medications are Lovaza omega-3 fatty acids , Tricor fenofibrate , Lopid gemfibrozil , Welchol colesevelam , and Zetia ezetimibe.

The best way to increase HDL is by exercising. Increasing the heart rate for 30 minutes a day for five days a week can provide beneficial results. Walking, swimming, and yoga are excellent options for part of your exercise regimen. Eating a diet that is low in saturated fat can help to reduce cholesterol levels. Eating more vegetables and lean meats like chicken breast or fish is a great way to eat healthy.

Speaking with a dietician or nutritionist may be helpful because they can help you to create a daily menu so that you eat low fat foods while still getting the calories and nutrients that you need.

Lopid gemfibrozil is used to reduce cholesterol and triglyceride levels in the blood. Other medications that can be used to reduce triglyceride levels are Tricor fenofibrate , Lofibra fenofibrate , Antara fenofibrate , and Triglide fenofibrate. Megan Uehara, PharmD Q: Can gemfibrozil cause cramping? Lopid gemfibrozil is a fibrate used mainly to reduce triglycerides, but it can also mildly reduce the "bad" LDL cholesterol and increase the "good" HDL cholesterol, and leg cramps are not listed as a side effect, but abdominal cramps, and muscle pain are.

Many people have taken Klor-con potassium and quinine to treat cramps, but in , the FDA banned the use of quinine, except Qualaquin used only for malaria , due to the risks on the heart being high.

There is quinine in tonic water, but not enough to reach a therapeutic dose. Foods high in potassium include bananas, apricots, cantaloupe, beets, figs, honeydew melon, and orange juice, which have at least mg per serving. Studies have looked at possible alternatives and have found some potentially positive results from Calan verapamil , Neurontin gabapentin , Soma carisoprodol , and Norflex orphenadrine.

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