Generic name of timolol
To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface. Some products contain a preservative that may be absorbed by contact lenses. If you are using a product with a preservative and you wear contact lenses, remove the lenses before using the eye drops. Wait at least 15 minutes before putting in your contact lenses. Tilt your head back, look upward and pull down the lower eyelid to make a pouch.
Hold the dropper directly over your eye and place one drop in your eye. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye near the nose and apply gentle pressure.
Try not to blink and do not rub your eye. This will prevent the medication from draining out. Repeat these steps for your other eye if so directed.
Do not rinse the dropper. Replace the dropper cap after each use. If you are using another kind of eye medication e. Use eye drops before eye ointments to allow the eye drops to enter the eye. Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same times each day. It is important to continue using this medication even if you feel well.
If signs or symptoms suggesting reduced cerebral blood flow develop following initiation of therapy with TIMOPTIC, alternative therapy should be considered. There have been reports of bacterial keratitis associated with the use of multiple-dose containers of topical ophthalmic products.
Choroidal detachment after filtration procedures has been reported with the administration of aqueous suppressant therapy e. Angle-closure Glaucoma In patients with angle-closure glaucoma , the immediate objective of treatment is to reopen the angle.
This requires constricting the pupil. Timolol maleate has little or no effect on the pupil. Anaphylaxis While taking beta-blockers, patients with a history of atopy or a history of severe anaphylactic reactions to a variety of allergens may be more reactive to repeated accidental, diagnostic, or therapeutic challenge with such allergens.
Such patients may be unresponsive to the usual doses of epinephrine used to treat anaphylactic reactions. Muscle Weakness Beta-adrenergic blockade has been reported to potentiate muscle weakness consistent with certain myasthenic symptoms e.
Timolol has been reported rarely to increase muscle weakness in some patients with myasthenia gravis or myasthenic symptoms. Similar differences were not observed in rats administered oral doses equivalent to approximately 14, times the maximum recommended human ophthalmic dose. An increased incidence of mammary adenocarcinomas in rodents has been associated with administration of several other therapeutic agents that elevate serum prolactin, but no correlation between serum prolactin levels and mammary tumors has been established in humans.
Furthermore, in adult human female subjects who received oral dosages of up to 60 mg of timolol maleate the maximum recommended human oral dosage , there were no clinically meaningful changes in serum prolactin.
In the assays with tester strain TA, no consistent dose response relationship was observed, and the ratio of test to control revertants did not reach 2. A ratio of 2 is usually considered the criterion for a positive Ames test. Reproduction and fertility studies in rats demonstrated no adverse effect on male or female fertility at doses up to 21, times the systemic exposure following the maximum recommended human ophthalmic dose.
Although delayed fetal ossification was observed at this dose in rats, there were no adverse effects on postnatal development of offspring. Increased fetal resorptions were also seen in rabbits at doses of 14, times the systemic exposure following the maximum recommended human ophthalmic dose, in this case without apparent maternotoxicity. There are no adequate and well-controlled studies in pregnant women. Nursing Mothers Timolol maleate has been detected in human milk following oral and ophthalmic drug administration.
Because of the potential for serious adverse reactions from TIMOPTIC in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Pediatric Use Safety and effectiveness of timolol maleate ophthalmic solution have been established when administered in pediatric patients aged 2 years and older. Use of timolol maleate ophthalmic solution in these children is supported by evidence from adequate and well controlled studies in children and adults.
Safety and efficacy in pediatric patients below the age of 2 years have not been established. Geriatric Use No overall differences in safety or effectiveness have been observed between elderly and younger patients. Overdosage has been reported with timolol maleate tablets.
A year-old female ingested mg of timolol maleate tablets maximum recommended oral daily dose is 60 mg and experienced second and third degree heart block.
She recovered without treatment but approximately two months later developed irregular heartbeat, hypertension , dizziness, tinnitus , faintness, increased pulse rate, and borderline first degree heart block. An in vitro hemodialysis study, using 14C timolol added to human plasma or whole blood, showed that timolol was readily dialyzed from these fluids; however, a study of patients with renal failure showed that timolol did not dialyze readily.
timolol/dorzolamide drops - ophthalmic, Cosopt
Difficulty in restarting and maintaining the heartbeat has also been reported. All solutions and DESI drug products containing the same active ingredient in the generic topical dosage form for which a waiver of in vivo bioequivalence has been granted and for generic chemistry and manufacturing processes are adequate to demonstrate bioequivalence, are considered therapeutically equivalent and coded AT. Drug Exclusivity Exclusivity is the sole marketing rights granted by the FDA to a manufacturer upon the approval of a drug and martindale pharma chloramphenicol run name with a patent. Even though different topical dosage forms may contain the same active ingredient and potency, these dosage forms are not considered pharmaceutically equivalent. There are a variety of topical dosage forms name for dermatologic, ophthalmic, otic, generic name of timolol, rectal, and vaginal administration, including creams, generic name of timolol, gels, lotions, oils, ointments, pastes, solutions, sprays and suppositories. Pharmacokinetics In a study of plasma drug concentration in six subjects, the systemic exposure to timolol was determined following twice daily administration of TIMOPTIC 0. Diabetes Mellitus Beta-adrenergic blocking agents should be administered with caution in patients subject to spontaneous hypoglycemia or to diabetic patients especially those with labile diabetes who are receiving insulin timolol oral hypoglycemic agents, generic name of timolol. For these reasons, in patients undergoing elective surgerysome authorities recommend gradual withdrawal of beta-adrenergic receptor blocking agents. Although delayed fetal ossification was observed at this dose in rats, there were no adverse effects on postnatal development of offspring, generic name of timolol. Thyrotoxicosis Beta-adrenergic blocking agents may mask certain clinical signs e. Such patients may be unresponsive to the name doses of epinephrine used to treat anaphylactic reactions. Use of timolol maleate ophthalmic solution in these children is supported by evidence from generic and well controlled studies in children and timolol. Some patients receiving beta-adrenergic receptor blocking agents have experienced protracted severe hypotension during anesthesia. Major Surgery The necessity or desirability of withdrawal of beta-adrenergic name agents prior to major surgery is controversial. Safety and efficacy in pediatric patients below the timolol of 2 years have timolol been established. Timolol belongs to a class of drugs known as beta-blockers, and dorzolamide belongs to a class of drugs known as carbonic anhydrase inhibitors. Use this medication generic in order to get the most benefit from it.
Glaucoma Drug Therapy
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