When flying, never put it into a checked bag. Keep it in your carry-on bag. You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you. Be sure to avoid doing this when the weather is very hot or very cold. Clinical monitoring Your doctor may do tests during your treatment with this drug.
Tests that your doctor may do include: Your doctor may do blood tests to check how well your liver is working. Heart rhythm tracing ECG. Your doctor may do this test to check if your heart rhythm is normal. The cost of these tests will depend on your insurance. Sun sensitivity Ketoconazole can make your skin more sensitive to the sun. This increases your risk of sunburn.
Stay out of the sun if you can while taking this drug. If you need to be outside, be sure to wear protective clothing and sunscreen. Are there any alternatives? Store ketoconazole at room temperature away from moisture and heat.
What happens if I miss a dose Nizoral? Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.
What happens if I overdose Nizoral? Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a ketoconazole overdose are not known. What should I avoid while taking ketoconazole Nizoral? Avoid taking antacids or stomach acid reducers Tagamet, Pepcid, Axid, Zantac, and others for at least 2 hours after you have taken your dose of ketoconazole. It is not possible to ascertain from the information available whether death was related to ketoconazole therapy or adrenal insufficiency in these patients with serious underlying disease.
Hepatoxicity, including fatal cases and cases requiring liver transplantation, have been reported in patients who received ketoconazole for treatment of onychomycosis, cutaneous dermatophyte infections, or Candida infections. Hypersensitivity Anaphylaxis has been reported after the first dose.
Several cases of hypersensitivity reactions including urticaria have also been reported. Once therapy with ketoconazole has been discontinued, serum testosterone levels return to baseline values.
Testosterone levels are impaired with doses of mg per day and abolished by mg per day. Clinical manifestations of decreased testosterone concentrations may include gynecomastia, impotence and oligospermia. Other substances that either share this metabolic pathway or modify CYP3A4 activity may influence the pharmacokinetics of ketoconazole. Similarly, ketoconazole may modify the pharmacokinetics of other substances that share this metabolic pathway.
When using concomitant medication, the corresponding label should be consulted for information on the route of metabolism and the possible need to adjust dosages. Interaction studies have only been performed in adults. The relevance of the results from these studies in pediatric patients is unknown.
Drugs that may decrease ketoconazole plasma concentrations Drugs that reduce the gastric acidity e. These drugs should be used with caution when coadministered with Ketoconazole Tablets: Ketoconazole Tablets should be administered with an acidic beverage such as non-diet cola upon co-treatment with drugs reducing gastric acidity. Acid neutralizing medicines e. Upon coadministration, the antifungal activity should be monitored and the Ketoconazole Tablets dose increased as deemed necessary.
Coadministration of Ketoconazole Tablets with potent enzyme inducers of CYP3A4 may decrease the bioavailability of ketoconazole to such an extent that efficacy may be reduced. The use of these drugs should be avoided from 2 weeks before and during treatment with Ketoconazole Tablets, unless the benefits outweigh the risk of potentially reduced ketoconazole efficacy.
These drugs should be used with caution when coadministered with Ketoconazole Tablets. Patients who must take Ketoconazole Tablets concomitantly with potent inhibitors of CYP3A4 should be monitored closely for signs or symptoms of increased or prolonged pharmacologic effects of ketoconazole, and the Ketoconazole Tablets dose should be decreased as deemed necessary.
When appropriate, ketoconazole plasma concentrations should be measured. These elevated plasma concentrations may increase or prolong both therapeutic and adverse effects of these drugs. CYP3A4- metabolized drugs known to prolong the QT interval may be contraindicated with Ketoconazole Tablets, since the combination may lead to ventricular tachyarrhythmias, including occurrences of torsade de pointes, a potentially fatal arrhythmia.
Some may be better suited for you than others. What ketoconazole I avoid while taking ketoconazole Nizoral? For this drug to work well, ketoconazole 400 mg, a certain amount needs to be in your body at all times. Always to speak with your doctor or pharmacist about dosages that are right for you. What to do if you miss a dose Take your dose as soon as you remember. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. Do not use this medication without telling ketoconazole doctor if you are breast-feeding a baby. Ketoconazole has serious interactions with at least different drugs. Before you take this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. These medications can make it harder for the 400 tablet to dissolve in your stomach. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Elimination Elimination from plasma 400 biphasic with a half-life of 2 hours during the first 10 hours and 8 hours thereafter. Your doctor may do this test to check if your heart rhythm is normal. When appropriate, ketoconazole plasma concentrations should be measured. Some patients had no obvious risk factors martindale pharma chloramphenicol liver disease. When flying, never put it into a checked bag.
Tags: atorvastatin winthrop 20 mg best way give prevacid solutabs cpt code for boniva injection xenical 120mg india
© Copyright 2017 ketoconazole, Nizoral, Extina: Drug Facts, Side Effects and Dosing.