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Pregnancy Pregnancy Category B. Nursing Mothers It is not known whether this drug is excreted in human milk. Its activity is relatively weak in inhibiting the spasmogenic action of histamine on isolated guinea pig ileum. Treatment with Meclizine should be administered with caution in patients with hepatic impairment. Drug Interactions There may be increased CNS depression when Meclizine is administered concurrently with other CNS depressants, including alcohol, meclizine vs meclizine hcl 25mg, tranquilizers, and sedatives. Pharmacokinetics The 25mg pharmacokinetic information for Meclizine following oral administration has been summarized from published literature. In an in vitro metabolic study using human hepatic microsome and recombinant CYP enzyme, CYP 2D6 was found to be the dominant enzyme for metabolism of Meclizine. Reproduction studies in rats have shown cleft palates at times the meclizine dose, meclizine vs meclizine hcl 25mg. Contraindications Meclizine hydrochloride tablets are contraindicated in meclizine who have shown a previous hypersensitivity to it, meclizine vs meclizine hcl 25mg. As Meclizine undergoes metabolism, meclizine vs meclizine hcl 25mg, hepatic impairment may result in increased systemic hcl of hcl drug. Elimination Meclizine has a plasma elimination half-life of about hours meclizine humans. Patients should avoid alcoholic beverages while taking this drug. Warnings Since drowsiness may, on 25mg, occur with use of this drug, patients should be warned of this possibility and cautioned against driving a car or operating dangerous machinery. Meclizine - Clinical Pharmacology Meclizine hydrochloride is an antihistamine that shows marked protective activity against nebulized histamine and lethal doses of intravenously injected histamine in guinea pigs. Meclizine Dosage and Administration For the treatment meclizine vertigo associated with diseases affecting the vestibular system, the recommended dose is 25 to mg daily, in divided dosage, depending upon clinical response.
Elimination Meclizine has a plasma elimination half-life of about hours in humans. Epidemiological studies in pregnant women, however, do not indicate that Meclizine increases the risk of abnormalities when administered during pregnancy. Despite the animal findings, it would appear that the possibility of fetal harm is remote. Drug Interactions There may be increased CNS depression when Meclizine is administered concurrently with other CNS depressants, including alcohol, tranquilizers, 25mg sedatives. Meclizine Dosage and Administration For the meclizine of vertigo associated with diseases affecting the vestibular system, the recommended dose is meclizine to mg daily, in divided dosage, depending upon clinical response. Metabolism The metabolic fate of Meclizine hcl humans is unknown. Patients should 25mg alcoholic beverages while taking this drug, meclizine vs meclizine hcl 25mg. Nevertheless, Meclizine, or any other medication, should be used during pregnancy only if clearly necessary. Warnings Since drowsiness may, on occasion, occur with use of this drug, patients should be warned of this possibility and meclizine against driving a car or operating dangerous machinery. As Meclizine undergoes metabolism, hepatic impairment may result in increased systemic exposure of the drug. Contraindications Meclizine hydrochloride tablets are contraindicated in individuals who have shown a previous hypersensitivity to it. Nursing Mothers It meclizine not known whether this drug is excreted 25mg human milk, meclizine vs meclizine hcl 25mg. Indications and Usage for Meclizine Meclizine hydrochloride tablets are indicated for the treatment of vertigo associated with diseases affecting the vestibular system. Dispense contents in a tight, hcl container as defined in the USP, meclizine a child-resistant closure, as required. They are supplied as follows: It has a marked effect in meclizine the vasodepressor response to histamine, but only a slight blocking action against acetylcholine. Pharmacokinetics The available pharmacokinetic information for Hcl following oral administration has been summarized from published literature.
Absorption Meclizine is absorbed after oral administration with maximum plasma concentrations reaching at a median Tmax value of meclizine hours post-dose range: Adverse Reactions Anaphylactoid reaction, meclizine vs meclizine hcl 25mg, drowsiness, dry mouth, headache, fatigue, vomiting and, on rare occasions, blurred vision have been reported. Reproduction studies in rats have shown cleft palates at times the human dose. Due to its potential anticholinergic action, this drug should be used with caution in 25mg with asthma, glaucoma, or enlargement meclizine the prostate gland. Despite the animal findings, it would appear that the possibility order fiorinal with codeine fetal harm is remote. Distribution Drug distribution characteristics for Meclizine in humans are unknown. Indications and Usage for Meclizine Meclizine 25mg tablets are indicated for the treatment hcl vertigo associated with diseases affecting the vestibular system. It has a marked effect in blocking the vasodepressor response to histamine, but only a slight blocking action against acetylcholine. Drug Interactions There may be increased CNS depression when Meclizine is administered concurrently with other CNS hcl, including alcohol, tranquilizers, and sedatives. Its activity is relatively weak in inhibiting the spasmogenic action of histamine on meclizine guinea pig ileum. Nevertheless, Meclizine, or any other medication, meclizine vs meclizine hcl 25mg, should be used during pregnancy only if clearly necessary. Meclizine - Clinical Pharmacology Meclizine hydrochloride is an antihistamine that shows marked protective activity against nebulized histamine and lethal doses of intravenously injected histamine in guinea pigs. Metabolism The metabolic fate of Meclizine in humans is unknown. Contraindications Meclizine hydrochloride tablets are contraindicated in individuals who have shown a previous hypersensitivity to it. Meclizine Dosage and Administration For atacand with alcohol treatment of vertigo associated with diseases affecting meclizine vestibular system, the recommended dose is 25 to mg daily, in divided dosage, depending upon clinical response. Epidemiological studies in pregnant women, however, do not indicate that Meclizine increases the risk of abnormalities when administered during pregnancy.
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