For children from 1 to 12 years old Take 1 dose, based on your child's weight, once daily, for 10 days or as long as prescribed. Tamiflu is not approved for flu prevention in children less than 1 year of age. FAQs Below are several commonly asked questions and their answers. If you have additional questions not covered here, be sure to ask your doctor. What should I do if I miss a dose of Tamiflu? If you forget to take your medicine, take the missed dose as soon as you remember, unless it is 2 hours or less before your next scheduled dose.
Then continue to take Tamiflu at the usual times. Do not take 2 doses at a time to make up for a missed dose. If you miss several doses, tell your doctor and follow the advice given to you. Coadministration of probenecid results in an approximate two-fold increase in exposure to oseltamivir carboxylate due to a decrease in active anionic tubular secretion in the kidney.
However, due to the safety margin of oseltamivir carboxylate, no dose adjustments are required when coadministering with probenecid. No clinically relevant pharmacokinetic interactions have been observed when coadministering oseltamivir with amoxicillin , acetaminophen , aspirin, cimetidine , antacids magnesium and aluminum hydroxides and calcium carbonates , rimantadine, amantadine , or warfarin. Microbiology Mechanism Of Action Oseltamivir phosphate is an ethyl ester prodrug requiring ester hydrolysis for conversion to the active form, oseltamivir carboxylate.
Oseltamivir carboxylate is an inhibitor of influenza virus neuraminidase affecting release of viral particles. Antiviral Activity The antiviral activity of oseltamivir carboxylate against laboratory strains and clinical isolates of influenza virus was determined in cell culture. The concentrations of oseltamivir carboxylate required for inhibition of influenza virus in cell culture were highly variable depending on the assay method used and the virus tested.
The relationship between the antiviral activity in cell culture, inhibitory activity in the neuraminidase assay, and the inhibition of influenza virus replication in humans has not been established. Resistance Cell culture studies: Influenza A virus isolates with reduced susceptibility to oseltamivir carboxylate have been recovered by serial passage of virus in cell culture in the presence of increasing concentrations of oseltamivir carboxylate.
Reduced susceptibility isolates have been obtained during treatment with oseltamivir and from sampling during community surveillance studies. Changes in the viral neuraminidase that have been associated with reduced susceptibility to oseltamivir carboxylate are summarized in Table 8.
The clinical impact of this reduced susceptibility is unknown. In some cases, HA substitutions were selected in conjunction with known NA resistance substitutions and may contribute to reduced susceptibility to oseltamivir; however, the impact of HA substitutions on antiviral activity of oseltamivir in humans is unknown and likely to be strain-dependent. Selection of influenza A viruses resistant to oseltamivir can occur at higher frequencies in children.
The frequency of resistance selection to oseltamivir and the prevalence of such resistant virus vary seasonally and geographically. Circulating seasonal influenza strains expressing neuraminidase resistance-associated substitutions have been observed in individuals who have not received oseltamivir treatment. The H1N1 influenza virus " swine flu " was almost uniformly susceptible to oseltamivir; however, the frequency of circulating resistant variants can change from season to season.
Cross-Resistance Cross-resistance between oseltamivir and zanamivir has been observed in neuraminidase biochemical assays. He revealed that KPSC recently interviewed 28 persons to fill the posts. We have told drug retailers to give a report every fortnight on stock position of Tamiflu. The reports will go to the assistant drug controller. Tamiflu will be available locally in the state within a week," Shetty explained.
But there're side-effects Doctors and chemists have warned that persons who consume Tamiflu without being diagnosed with H1N1 flu and without prescription, may suffer from side-effects. According to deputy director of state surveillance unit Vasudeva Murthy, Tamiflu is supplied by the Union health ministry for free. The cost is likely to vary according to the company from which it's bought. Download The Times of India news app for your device.
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