Losartan is equally effective in males and females, and in younger below the age of 65 years and older hypertensive patients. Patients were randomised to once daily Losartan 50 mg or once daily atenolol 50 mg. Other antihypertensives, with the exception of ACE-inhibitors, angiotensin II antagonists or beta-blockers were added if necessary to reach the goal blood pressure. The mean length of follow up was 4. The primary endpoint was the composite of cardiovascular morbidity and mortality as measured by a reduction in the combined incidence of cardiovascular death, stroke and myocardial infarction.

Blood pressure was significantly lowered to similar levels in the two groups. Treatment with losartan resulted in a This was mainly attributable to a reduction of the incidence of stroke. The rates of cardiovascular death and myocardial infarction were not significantly different between the treatment groups. RENAAL study was a controlled clinical study conducted worldwide in Type 2 diabetic patients with proteinuria, with or without hypertension.

The objective of the study was to demonstrate a nephroprotective effect of Losartan potassium over and above the benefit of lowering blood pressure. Patients with proteinuria and a serum creatinine of 1. Other antihypertensive agents diuretics, calcium antagonists, alpha- and beta-receptor blockers and also centrally acting antihypertensives were permitted as supplementary treatment depending on the requirement in both groups.

Patients were followed up for up to 4. The primary endpoint of the study was a composite endpoint of doubling of the serum creatinine end-stage renal failure need for dialysis or transplantation or death. The results showed that the treatment with Losartan events as compared with placebo events resulted in a For the following individual and combined components of the primary endpoint, the results showed a significant risk reduction in the group treated with Losartan: All-cause mortality rate was not significantly different between the two treatment groups.

In this study losartan was generally well tolerated, as shown by a therapy discontinuation rate on account of adverse reactions that was comparable to the placebo group.

Patients were randomised to receive losartan 50 mg once a day or losartan mg, on a background of conventional therapy excluding ACE-inhibitors. Patients were followed for over 4 years median 4. The primary endpoint of the study was a composite endpoint of all cause death or hospitalization for heart failure. The results showed that treatment with mg losartan events as compared with 50 mg losartan events resulted in a This was mainly attributable to a reduction of the incidence of hospitalization for heart failure.

Treatment with mg losartan reduced the risk of hospitalization for heart failure by The rate of all cause death was not significantly different between the treatment groups.

Renal impairment, hypotension, and hyperkalaemia were more common in the mg group than in the 50 mg group, but these adverse events did not lead to significantly more treatment discontinuations in the mg group. The primary endpoint of this prospective study was the all-cause mortality.

The primary endpoint did not show any statistically significant difference between Losartan and captopril in reducing all-cause mortality. In both comparator-controlled not placebo-controlled clinical studies on patients with heart failure the tolerability of Losartan was superior to that of captopril, measured on the basis of a significantly lower rate of discontinuations of therapy on account of adverse reactions and a significantly lower frequency of cough.

The dose-response relationship became very obvious in the low dose group compared to the middle dose group period I: The lowest doses studied, 2. These results were confirmed during period II of the study where patients were randomized to continue losartan or placebo, after three weeks of treatment. The difference in blood pressure increase as compared to placebo was largest in the middle dose group 6. The rise in trough diastolic blood pressure was the same in patients receiving placebo and in those continuing losartan at the lowest dose in each group, again suggesting that the lowest dose in each group did not have significant antihypertensive effect.

Long-term effects of losartan on growth, puberty and general development have not been studied. The long-term efficacy of antihypertensive therapy with losartan in childhood to reduce cardiovascular morbidity and mortality has also not been established. Losartan was given at doses of 0. Amlodipine was given at doses of 0. Hypertensive patients receiving losartan experienced a reduction from baseline proteinuria of The decline in both systolic blood pressure and diastolic blood pressure was greater in the losartan group In normotensive children a small decrease in blood pressure was observed in the losartan group No significant correlation between the decline in proteinuria and blood pressure was noted, however it is possible that the decline in blood pressure was responsible, in part, for the decline in proteinuria in the losartan treated group.

Long-term effects of losartan in children with proteinuria were studied for up to 3 years in the open-label safety extension phase of the same study, in which all patients completing the week base study were invited to participate. ONTARGET was a study conducted in patients with a history of cardiovascular or cerebrovascular disease, or type 2 diabetes mellitus accompanied by evidence of end-organ damage.

Given their similar pharmacodynamic properties, these results are also relevant for other ACE-inhibitors and angiotensin II receptor blockers. ACE-inhibitors and angiotensin II receptor blockers should therefore not be used concomitantly in patients with diabetic nephropathy. The study was terminated early because of an increased risk of adverse outcomes. For information, talk to your doctor. Zovencal Tablets may have a minor or moderate effect on your ability to drive and use machines.

They may cause dizziness, feeling of weakness and vertigo. If you experience any of these side effects then you should not drive or use machines. Zovencal 25mg, 50mg and mg Tablets contains lactose These tablets contain lactose so if you suffer from rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose galactose malabsorption then you should not take this medicine.

Check with your doctor or pharmacist if you are not sure. Zovencal Tablets should be taken by mouth. You must keep taking Zovencal Tablets every day and exactly as your doctor has told you. It is recommended that you take your tablet at the same time each day. Dose Instructions for Adults The usual dose of Losartan Potassium Tablets for most adult patients is one 50mg tablet once a day to control blood pressure over the 24 hour period.

However, in certain patients such as those over 75 years of age or those with kidney or liver problems, the doctor may prescribe a lower dose of 25 mg once a day. Alternatively, the doctor may prescribe a higher dose i. Use in Children Hypertension in Children aged 6 to 16 years old For children who can swallow tablets, and who weigh between 20 and 50 kg, the recommended dose is 25 mg once daily.

The dose can be increased to a maximum of 50 mg once daily. For children who weigh 50 kg or over, the starting dose is 50 mg once daily. The dose can be increased to a maximum of mg once daily. The doctor will adjust the dosage according to the weight of the child and their blood pressure response.

Dosage in special patient groups The doctor may advise a lower dose, especially when starting treatment in certain patients such as those treated with diuretics in high doses, in patients with liver impairment, or in patients over the age of 75 years. The use of losartan is not recommended in patients with severe hepatic impairment.

If you take more Zovencal 25mg, 50mg and mg Tablets than you should If you take an overdose by mistake, contact your doctor immediately or attend the nearest hospital casualty department. If you forget to take Zovencal 25mg, 50mg and mg Tablets Try to take Zovencal Tablets daily as prescribed.

Cómo el Losartan Potassium 50 mg ayuda a reducir la presión arterial

Zovencal 25mg, losartan 50 mg espanol, 50mg and mg Tablets with food and drink Zovencal Tablets does not usually interact with food therefore losartan can be administered with losartan without food. They may cause dizziness, feeling of weakness and vertigo. The pharmacokinetics of losartan generic viagra legal its active metabolite are linear with oral losartan potassium doses up to mg, losartan 50 mg espanol. You may need urgent medical attention or hospitalization. Characteristics in patients In elderly hypertensive patients the plasma concentrations of losartan and its active metabolite do not differ essentially from those found in young hypertensive patients. For the following individual and combined components of the primary endpoint, the results showed a significant risk reduction in the group treated with Losartan: The study was terminated early because of an increased risk of adverse outcomes, losartan 50 mg espanol. Your doctor will normally advise you to stop taking Losartan tablets before you become pregnant or as soon as you know you are pregnant and will advise you espanol take another medicine instead of Losartan tablets. When comparing preschool children with adolescents these differences became statistically significant, losartan 50 mg espanol. Treatment of intoxication If symptomatic hypotension should occur, losartan 50 mg espanol, supportive treatment should be instituted. Angiotensin II binds to the AT1 receptor found in many tissues e. The results showed that the treatment with Losartan events as compared with placebo events resulted in a Espanol pharmacokinetic parameters for the metabolite differed to a greater extent between the age groups. In this study losartan was generally losartan tolerated, as shown by a therapy discontinuation rate on account of adverse reactions that espanol comparable to the placebo group. Both Losartan and its losartan active metabolite have a far greater affinity for the Espanol than for the AT2-receptor. Patients with proteinuria and a serum creatinine of 1.

Losartan Potassium 50 mg Film-coated Tablets

Do not take an extra tablet to make up. All-cause mortality rate losartan not significantly different between the two treatment groups. In repeated dose toxicity studies, the administration of losartan induced a decrease in famotidine 10mg dogs red blood cell parameters erythrocytes, losartan 50 mg espanol, haemoglobin, haematocrita rise in urea-N in the serum and occasional rises in serum creatinine, a decrease in heart weight without a histological correlate and gastrointestinal changes mucous membrane lesions, ulcers, erosions, haemorrhages, losartan 50 mg espanol. If you have any further questions about taking this product, ask your doctor or pharmacist. In normotensive children a small decrease in better tetracycline doxycycline pressure was observed in the losartan group The rates of cardiovascular death and myocardial infarction were not significantly different between the treatment groups. Patients were followed up for up to 4. Long-term effects of losartan on growth, espanol and general development have not been studied. Pregnancy and breast-feeding You must tell your doctor if you think you are pregnant, or might become pregnant. Patients were randomised to once daily Losartan 50 mg or once daily atenolol 50 mg. However, in certain patients such as those over 75 years of age or those with kidney or liver problems, the doctor may prescribe a lower dose of 25 mg once a day. The results showed that the treatment with Losartan events as compared with placebo events resulted in a Bradycardia could occur from parasympathetic vagal stimulation. You may need urgent medical attention or hospitalization. Angiotensin II also stimulates smooth muscle cell proliferation. The mean length of follow up was 4.

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